KLF5

Across TCGA cell cohorts, KLF5 mutation is significantly associated with the drug of many other genes, with 65 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLF5-associated genes across cancer lineages are Cytarabine, ZM447439, and RO-3306. Each is linked with KLF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF5-to-partner and partner-to-KLF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytarabine grouped by KLF5-low versus KLF5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF5→partner) and Y-score (partner→KLF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cytarabine →	+0.784	+2.655	.044	.044	2	2
LARGE_INTESTINE	ZM447439 →	+0.522	+2.807	.044	.046	3	1
LARGE_INTESTINE	RO-3306 →	+0.615	+2.807	.015	.035	3	1
LARGE_INTESTINE	GSK1904529A →	+0.333	+2.678	.036	.037	3	1
LARGE_INTESTINE	RAF_9304 →	+0.480	+2.649	.040	.046	3	1
LARGE_INTESTINE	IGF1R_3801 →	+0.747	+2.871	.007	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Cytarabine by KLF5 expression — LARGE_INTESTINE

Explore this box plot interactively →