KLF4

Across TCGA patient cohorts, KLF4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,268 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLF4-associated genes across cancer lineages are CEACAM5, GLS, and TNS4. Each is linked with KLF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLF4-to-partner and partner-to-KLF4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF4 versus CEACAM5 in LSCC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF4→partner) and Y-score (partner→KLF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEACAM5 →	+2.339	+0.803	<.001	<.001	3	3
LUAD	GLS →	-0.902	-0.986	.001	.002	3	3
LUAD	TNS4 →	+1.541	+1.056	.001	<.001	3	3
HNSC	SPINK5 →	+1.861	+0.584	<.001	.001	3	3
LSCC	ZNF750 →	+1.028	+0.898	<.001	<.001	3	3
LSCC	IVL →	+2.357	+0.853	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,268 associations by consensus.

KLF4 vs CEACAM5 — LSCC

Explore this scatter interactively →