KLF4

Across TCGA cell cohorts, KLF4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLF4-associated genes across cancer lineages are KCNK17, GNGT1, and FRMD1. Each is linked with KLF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF4-to-partner and partner-to-KLF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNK17 grouped by KLF4-low versus KLF4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF4→partner) and Y-score (partner→KLF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KCNK17 →	+0.027	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	GNGT1 →	+0.405	+4.459	<.001	.001	3	1
BLOOD_Lymphoma	FRMD1 →	+0.525	+3.793	<.001	.007	3	1
BLOOD_Lymphoma	C7orf33 →	+1.018	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	PROP1 →	+0.009	+4.452	.002	.001	3	1
BLOOD_Lymphoma	OR56A1 →	+0.036	+3.523	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

KCNK17 by KLF4 expression — BLOOD_Lymphoma

Explore this box plot interactively →