KLF3

Across TCGA pan-cancer cohorts, KLF3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLF3 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher KLF3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLF3 expression acts as an unfavorable survival marker.

OV, BRCA, and COAD are the cancer types where KLF3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.028	0.844	<.001	48	view →
BRCA	OS	Median	All	0.656	0.924	<.001	34	view →
COAD	OS	Median	IV	0.056	0.649	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLF3–OV (OS)

Open the OV breakdown →