KLF3

Across TCGA pan-cancer cohorts, KLF3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KLF3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where KLF3 RNA is repressed in tumor relative to normal tissue. In most cancer types KLF3 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

THCA, READ, and KICH are the cancer types where KLF3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.627	<.001	8	view →
READ	All	All	−0.663	.002	6	view →
KICH	Female	All	−1.043	<.001	5	view →
COAD	Female	All	−0.847	<.001	5	view →
UCEC	All	All	−0.910	<.001	4	view →
CHOL	All	All	+0.795	<.001	4	view →
BRCA	All	All	−0.210	.002	4	view →
PAAD	All	All	+0.629	.012	2	view →
LUAD	Female	All	−0.241	.030	1	view →
LUSC	All	All	+0.222	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KLF3–THCA

Open the THCA breakdown →