KLF3

Across TCGA patient cohorts, KLF3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,615 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLF3-associated genes across cancer lineages are ITGAX, VSIG10, and CLEC5A. Each is linked with KLF3 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLF3-to-partner and partner-to-KLF3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF3 versus ITGAX in HNSC, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF3→partner) and Y-score (partner→KLF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ITGAX →	-0.756	-0.652	<.001	<.001	3	4
BRCA	VSIG10 →	+0.559	+0.409	<.001	<.001	3	4
LUAD	CLEC5A →	-0.762	-0.235	.001	<.001	3	4
HNSC	SP140 →	-0.788	-0.393	<.001	.004	3	4
HNSC	SUDS3P1 →	+0.539	+0.409	.001	.005	3	4
LSCC	RMND5A →	+0.710	+0.290	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,615 associations by consensus.

KLF3 vs ITGAX — HNSC

Explore this scatter interactively →