KLF3

Across TCGA patient cohorts, KLF3 mutation is significantly associated with the RNA expression of many other genes, with 1,065 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF3-associated genes across cancer lineages are TRAJ12, TRAF6P1, and RNU6-1036P. Each is linked with KLF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLF3-to-partner and partner-to-KLF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ12 grouped by KLF3-low versus KLF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF3→partner) and Y-score (partner→KLF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ12 →	+0.440	+1.844	.002	.003	3	3
SKCM	TRAF6P1 →	+0.034	+3.296	<.001	<.001	3	2
BRCA	RNU6-1036P →	+0.352	+7.731	<.001	.009	3	2
HNSC	RN7SKP191 →	+0.102	+5.608	<.001	.002	3	2
HNSC	RNU6-99P →	+0.267	+6.132	<.001	.001	3	2
UCEC	NFATC4 →	-0.749	-1.883	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,065 associations by consensus.

TRAJ12 by KLF3 expression — UCEC

Explore this box plot interactively →