KLF3

Across TCGA cell cohorts, KLF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,272 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLF3-associated GO terms across cancer lineages are Response to endothelin, Cellular response to endothelin, and Maintenance of blood-brain barrier. Each is linked with KLF3 in more than 12 cancer types. Because this analysis shows association rather than direction, both KLF3-to-partner and partner-to-KLF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endothelin grouped by KLF3-low versus KLF3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF3→partner) and Y-score (partner→KLF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Response to endothelin →	+0.899	+1.568	<.001	<.001	3	13
BLOOD_Leukemia	Cellular response to endothelin →	+0.883	+1.409	<.001	<.001	3	13
STOMACH	Maintenance of blood-brain barrier →	+0.224	+1.667	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of endoplasmic reticulum unfolded protein response →	+0.126	+1.547	<.001	<.001	3	11
PANCREAS	Regulation of canonical Wnt signaling pathway →	+0.048	+0.656	.002	.004	3	11
OVARY	Negative regulation of MAPK cascade →	+0.049	+0.765	.003	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,272 associations by consensus.

Response to endothelin by KLF3 expression — BLOOD_Leukemia

Explore this box plot interactively →