KLF3

Across TCGA cell cohorts, KLF3 mutation is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLF3-associated genes across cancer lineages are NKX2-6, TLE7, and HSCB. Each is linked with KLF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF3-to-partner and partner-to-KLF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by KLF3-low versus KLF3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF3→partner) and Y-score (partner→KLF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	HSCB →	+0.632	+3.169	.001	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.661	+3.451	<.001	.002	3	1
LARGE_INTESTINE	PHF5A →	+0.560	+3.364	.002	.002	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.693	+3.451	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

NKX2-6 by KLF3 expression — BLOOD_Leukemia

Explore this box plot interactively →