KLF17

Across TCGA pan-cancer cohorts, KLF17 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KLF17’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLF17 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLF17 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

HNSC, LUAD, and BLCA are the cancer types where KLF17 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF17 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.120	<.001	11	view →
LUAD	Female	III,IV	−0.514	<.001	9	view →
BLCA	All	III,IV	−1.315	.001	8	view →
LUSC	Female	All	−0.622	<.001	8	view →
UCEC	All	All	−1.147	<.001	6	view →
BRCA	Female	All	+0.241	<.001	4	view →
LIHC	Female	All	+0.018	.003	3	view →
STAD	Male	IV	+0.115	.016	1	view →
COAD	Male	IV	+0.102	.035	1	view →
KIRC	Male	All	+0.023	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KLF17–HNSC

Open the HNSC breakdown →