KLF16

Across TCGA cell cohorts, KLF16 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,689 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLF16-associated GO terms across cancer lineages are Cytoplasm protein quality control by the ubiquitin-proteasome system, Cytoplasm protein quality control, and Protein-DNA complex disassembly. Each is linked with KLF16 in more than 15 cancer types. Because this analysis shows association rather than direction, both KLF16-to-partner and partner-to-KLF16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasm protein quality control by the ubiquitin-proteasome system grouped by KLF16-low versus KLF16-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF16→partner) and Y-score (partner→KLF16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.274	+1.041	<.001	<.001	3	16
BONE	Cytoplasm protein quality control →	+0.235	+1.030	<.001	<.001	3	16
BLOOD_Myeloma	Protein-DNA complex disassembly →	+0.159	+0.928	<.001	<.001	3	12
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.154	+0.666	.001	.002	3	11
BONE	Transcription pausing by RNA polymerase II →	+0.253	+0.940	<.001	<.001	3	10
BREAST	Positive regulation of phospholipase C/protein kinase C signal transduction →	+0.264	+0.509	.009	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,689 associations by consensus.

Cytoplasm protein quality control by the ubiquitin-proteasome system by KLF16 expression — BONE

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