KLF16

Across TCGA pan-cancer cohorts, KLF16 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KLF16 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KLF16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLF16 expression acts as an unfavorable survival marker, although some lineages such as SCLC and STAD show a favorable association.

ACC, MESO, and KIRC are the cancer types where KLF16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.229	0.644	<.001	149	view →
MESO	OS	Median	All	0.399	0.676	<.001	113	view →
KIRC	OS	Tertile	All	0.725	0.884	<.001	93	view →
LUAD	OS	Tertile	All	0.750	0.850	.001	45	view →
BRCA	DFS	Tertile	II,III,IV	0.906	0.956	.011	43	view →
LGG	DFS	Median	All	0.648	0.821	<.001	37	view →
SCLC	OS	Quartile	All	0.825	0.524	.003	36	view →
KIRP	DFS	Median	II,III,IV	0.551	0.799	.007	35	view →
LIHC	OS	Median	III,IV	0.515	0.766	.002	32	view →
OV	OS	Median	III,IV	0.259	0.372	.001	24	view →
KICH	OS	Quartile	III,IV	0.228	1.000	.017	23	view →
BLCA	DFS	Median	All	0.198	0.477	.017	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KLF16–ACC (DFS)

Open the ACC breakdown →