KLF15

Across TCGA patient cohorts, KLF15 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF15-associated genes across cancer lineages are eIF4E, EGFR_pY1068, and INPP4B. Each is linked with KLF15 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLF15-to-partner and partner-to-KLF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by KLF15-low versus KLF15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF15→partner) and Y-score (partner→KLF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.250	+3.013	.006	.018	3	3
UCEC	EGFR_pY1068 →	-0.289	-2.807	.008	.003	3	2
UCEC	INPP4B →	-0.393	-2.584	.005	.010	3	2
UCEC	Annexin-1 →	+0.594	+2.115	.009	.019	3	2
UCEC	Stathmin →	+0.162	+2.115	.007	.019	3	2
UCEC	4E-BP1 →	+0.286	+2.999	.015	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by KLF15 expression — UCEC

Explore this box plot interactively →