KLF14

Across TCGA patient cohorts, KLF14 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF14-associated genes across cancer lineages are IRS1, JNK2, and MEK1. Each is linked with KLF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF14-to-partner and partner-to-KLF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by KLF14-low versus KLF14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF14→partner) and Y-score (partner→KLF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	+0.272	+2.321	.004	.034	3	1
UCEC	JNK2 →	+0.344	+3.026	<.001	.018	3	1
UCEC	MEK1 →	+0.529	+3.459	.001	.005	3	1
UCEC	NF2 →	+0.355	+2.584	<.001	.011	3	1
UCEC	p62 Lck ligand →	+0.312	+2.999	.039	.035	3	1
UCEC	Rab25 →	-0.449	-3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

IRS1 by KLF14 expression — UCEC

Explore this box plot interactively →