KLF14

Across TCGA cell cohorts, KLF14 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,313 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible KLF14-associated GO terms across cancer lineages are DNA-templated transcription initiation, Sensory perception of mechanical stimulus, and 7-methylguanosine cap hypermethylation. Each is linked with KLF14 in more than 11 cancer types. Because this analysis shows association rather than direction, both KLF14-to-partner and partner-to-KLF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by KLF14-low versus KLF14-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF14→partner) and Y-score (partner→KLF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DNA-templated transcription initiation →	+0.053	+0.318	.001	.001	3	12
STOMACH	Sensory perception of mechanical stimulus →	-0.058	-0.378	.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	7-methylguanosine cap hypermethylation →	+0.082	+0.249	.001	.004	3	8
BREAST	Protein monoubiquitination →	+0.082	+0.189	<.001	<.001	3	8
LARGE_INTESTINE	Cardiac muscle cell action potential →	-0.144	-0.137	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.075	+0.169	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,313 associations by consensus.

DNA-templated transcription initiation by KLF14 expression — URINARY_TRACT

Explore this box plot interactively →