KLF1

Across TCGA patient cohorts, KLF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,718 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLF1-associated proteins across cancer lineages are HIRIP3_S125, RPRD2, and ZNF106_S1026. Each is linked with KLF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLF1-to-partner and partner-to-KLF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF1 versus HIRIP3_S125 in UCEC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF1→partner) and Y-score (partner→KLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIRIP3_S125 →	+0.487	+0.259	<.001	<.001	3	4
LSCC	RPRD2 →	+0.404	+0.325	<.001	<.001	3	4
LSCC	ZNF106_S1026 →	+0.564	+0.215	<.001	.003	3	3
BRCA	PRPF19 →	+0.209	+0.281	.005	<.001	3	3
LSCC	ZNF638 →	+0.317	+0.277	<.001	<.001	3	3
UCEC	SPC25 →	+0.562	+0.290	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,718 associations by consensus.

KLF1 vs HIRIP3_S125 — UCEC

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