KLF1

Across TCGA pan-cancer cohorts, KLF1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated KLF1 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KLF1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KLF1 expression acts as an unfavorable survival marker, although some lineages such as CESC and HNSC show a favorable association.

CESC, HNSC, and ACC are the cancer types where KLF1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.617	0.229	.001	96	view →
HNSC	DFS	Median	All	0.776	0.643	<.001	94	view →
ACC	OS	Quartile	II,III,IV	0.538	0.831	.005	47	view →
LGG	DFS	Median	All	0.821	0.653	<.001	45	view →
UCEC	OS	Quartile	All	0.799	0.908	.006	16	view →
STAD	OS	Quartile	III,IV	0.772	0.461	.002	15	view →
KIRC	OS	Tertile	All	0.757	0.853	.015	12	view →
UCS	OS	Tertile	IV	0.205	0.783	.024	12	view →
THCA	DFS	Median	All	0.967	0.917	.018	11	view →
SCLC	DFS	Median	II,III,IV	0.819	0.205	.004	9	view →
BLCA	OS	Tertile	III,IV	0.445	0.106	.020	5	view →
MESO	DFS	Median	All	0.203	0.312	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

KLF1–CESC (OS)

Open the CESC breakdown →