KLF1

Across TCGA patient cohorts, KLF1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,331 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLF1-associated genes across cancer lineages are TMEM130, KLHDC8A, and CLCN5. Each is linked with KLF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLF1-to-partner and partner-to-KLF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLF1 versus TMEM130 in GBM, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF1→partner) and Y-score (partner→KLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM130 →	+2.158	+0.946	<.001	.001	3	3
COAD	KLHDC8A →	+0.415	+0.875	.001	<.001	3	2
COAD	CLCN5 →	+0.673	+0.508	.002	.003	3	2
PDAC	CPEB1-AS1 →	+0.068	+0.917	<.001	<.001	3	2
GBM	STMN2 →	+3.101	+0.903	.001	.001	3	2
GBM	RUNDC3A →	+1.625	+0.930	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,331 associations by consensus.

KLF1 vs TMEM130 — GBM

Explore this scatter interactively →