KLF1

Across TCGA patient cohorts, KLF1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF1-associated genes across cancer lineages are Lck, Src, and Axl. Each is linked with KLF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF1-to-partner and partner-to-KLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by KLF1-low versus KLF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF1→partner) and Y-score (partner→KLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.272	+3.000	.019	.037	3	1
UCEC	Src →	+0.262	+3.000	.027	.037	3	1
UCEC	Axl →	+0.258	+3.036	.031	.018	3	1
UCEC	B-Raf →	-0.458	-3.000	.027	.037	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Lck by KLF1 expression — UCEC

Explore this box plot interactively →