KLF1

Across TCGA cell cohorts, KLF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,235 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLF1-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Positive regulation of calcium ion transport into cytosol, and Receptor-mediated endocytosis. Each is linked with KLF1 in more than 9 cancer types. Because this analysis shows association rather than direction, both KLF1-to-partner and partner-to-KLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by KLF1-low versus KLF1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF1→partner) and Y-score (partner→KLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.067	+0.363	.009	.004	3	10
BONE	Positive regulation of calcium ion transport into cytosol →	-0.354	-0.441	<.001	<.001	3	9
CNS	Receptor-mediated endocytosis →	-0.060	-0.072	<.001	<.001	3	9
BONE	rRNA metabolic process →	+0.090	+0.278	<.001	<.001	3	8
BONE	Regulation of plasma membrane repair →	-0.395	-0.452	<.001	<.001	3	8
BONE	Regulation of leukocyte migration →	-0.109	-0.234	.002	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,235 associations by consensus.

Epigenetic regulation of gene expression by KLF1 expression — BONE

Explore this box plot interactively →