KLF1

Across TCGA cell cohorts, KLF1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLF1-associated genes across cancer lineages are KERA, CRYAA, and CCKAR. Each is linked with KLF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF1-to-partner and partner-to-KLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KERA grouped by KLF1-low versus KLF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF1→partner) and Y-score (partner→KLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KERA →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	CRYAA →	+0.065	+4.705	<.001	.003	3	1
BLOOD_Leukemia	CCKAR →	+0.043	+4.409	<.001	.005	3	1
BLOOD_Leukemia	NKX2-6 →	+0.452	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.098	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CCT8L2 →	+0.014	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

KERA by KLF1 expression — BLOOD_Leukemia

Explore this box plot interactively →