KLF1

Across TCGA cell cohorts, KLF1 mutation is significantly associated with the mutation status of many other genes, with 2,080 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLF1-associated genes across cancer lineages are DKK3, GLE1, and LTBP2. Each is linked with KLF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLF1-to-partner and partner-to-KLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DKK3 grouped by KLF1-low versus KLF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF1→partner) and Y-score (partner→KLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DKK3 →	+5.145	+5.145	<.001	<.001	1	3
CNS	GLE1 →	+5.044	+5.614	.003	.003	1	3
BLOOD_Leukemia	LTBP2 →	+3.145	+3.932	.004	.004	1	3
BLOOD_Leukemia	ZNF831 →	+2.823	+3.665	.008	.008	1	3
BLOOD_Leukemia	POSTN →	+4.238	+5.662	<.001	<.001	1	3
CNS	AXIN1 →	+4.044	+5.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,080 associations by consensus.

DKK3 by KLF1 expression — BLOOD_Leukemia

Explore this box plot interactively →