KLC4

Across TCGA patient cohorts, KLC4 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLC4-associated genes across cancer lineages are FASN, mTOR_pS2448, and p62 Lck ligand. Each is linked with KLC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLC4-to-partner and partner-to-KLC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by KLC4-low versus KLC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC4→partner) and Y-score (partner→KLC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.398	+1.678	.008	.023	3	2
UCEC	mTOR_pS2448 →	-0.145	-2.787	.011	.003	3	2
UCEC	p62 Lck ligand →	+0.290	+1.594	.020	.042	3	2
UCEC	Cyclin-B1 →	+0.477	+2.000	.027	.030	3	2
UCEC	JNK_pT183_Y185 →	-0.184	-2.807	.004	.003	3	1
UCEC	Notch1 →	+0.145	+1.594	.007	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FASN by KLC4 expression — UCEC

Explore this box plot interactively →