KLC4

Across TCGA pan-cancer cohorts, KLC4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KLC4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where KLC4 RNA is repressed in tumor relative to normal tissue. In most cancer types KLC4 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where KLC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.697	<.001	11	view →
COAD	Female	II,III,IV	−0.883	<.001	10	view →
THCA	Male	III,IV	−0.469	<.001	10	view →
LUAD	All	III,IV	−0.562	<.001	9	view →
LUSC	Male	All	−0.568	<.001	6	view →
KIRC	All	All	+0.329	<.001	6	view →
BLCA	Male	III,IV	−1.088	.004	5	view →
CHOL	All	All	−0.480	<.001	3	view →
READ	All	II,III,IV	−1.194	.026	2	view →
HNSC	Male	III,IV	+0.412	.021	2	view →
UCEC	All	All	−0.285	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

KLC4–KICH

Open the KICH breakdown →