KLC4

Across TCGA cell cohorts, KLC4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLC4-associated genes across cancer lineages are CLEC10A, MRGPRG, and GUCA2A. Each is linked with KLC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLC4-to-partner and partner-to-KLC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC10A grouped by KLC4-low versus KLC4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC4→partner) and Y-score (partner→KLC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLEC10A →	+0.035	+3.688	<.001	.002	3	1
SKIN	MRGPRG →	+0.013	+4.022	<.001	.006	3	1
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1
LARGE_INTESTINE	KLHL14 →	+0.146	+3.554	.002	.007	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CLEC10A by KLC4 expression — SKIN

Explore this box plot interactively →