KLC3

Across TCGA patient cohorts, KLC3 protein abundance is significantly associated with the RNA expression of many other genes, with 10,150 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLC3-associated genes across cancer lineages are SPIRE1, DUSP14, and ULBP2. Each is linked with KLC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLC3-to-partner and partner-to-KLC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLC3 versus SPIRE1 in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC3→partner) and Y-score (partner→KLC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPIRE1 →	+1.195	+0.782	<.001	<.001	3	4
LSCC	DUSP14 →	+0.891	+0.767	<.001	<.001	3	4
HNSC	ULBP2 →	+1.193	+0.712	<.001	<.001	3	4
CCRCC	ABL2 →	+0.467	+0.470	.003	.007	3	4
HNSC	ADGRF4 →	+1.335	+0.669	<.001	<.001	3	4
LSCC	YEATS2 →	+0.683	+0.562	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,150 associations by consensus.

KLC3 vs SPIRE1 — UCEC

Explore this scatter interactively →