KLC1

Across TCGA pan-cancer cohorts, KLC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLC1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KLC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and UCEC are the cancer types where KLC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.983	0.902	.008	16	view →
CCRCC	DFS	Tertile	IV	0.961	0.191	.017	12	view →
UCEC	DFS	Quartile	All	0.977	0.768	.006	10	view →
PDAC	OS	Quartile	II,III,IV	0.890	0.781	.029	4	view →
LUAD	OS	Median	III,IV	0.337	0.765	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLC1–HNSC (DFS)

Open the HNSC breakdown →