KLC1

Across TCGA pan-cancer cohorts, KLC1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KLC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KLC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KLC1 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where KLC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.515	<.001	11	view →
LIHC	All	II,III,IV	+0.580	<.001	9	view →
COAD	Female	All	+0.390	<.001	7	view →
BRCA	Female	All	−0.286	<.001	6	view →
CHOL	Male	All	+1.726	<.001	5	view →
LUAD	All	All	−0.314	.002	3	view →
KICH	All	All	−0.397	.003	2	view →
READ	Male	All	+0.346	.033	2	view →
KIRC	All	All	+0.173	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

KLC1–HNSC

Open the HNSC breakdown →