KLC1

Across TCGA patient cohorts, KLC1 mutation is significantly associated with the RNA expression of many other genes, with 3,214 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLC1-associated genes across cancer lineages are MIR6075, RN7SL478P, and RNU6-101P. Each is linked with KLC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLC1-to-partner and partner-to-KLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6075 grouped by KLC1-low versus KLC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC1→partner) and Y-score (partner→KLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6075 →	+0.209	+2.114	.001	.001	3	3
UCEC	RN7SL478P →	+0.177	+1.691	<.001	.001	3	3
CESC	RNU6-101P →	+0.459	+4.339	<.001	.002	3	2
UCEC	SMARCE1P2 →	+0.123	+2.123	.002	<.001	3	2
CESC	LINC02558 →	+0.407	+5.254	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.467	+1.896	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,214 associations by consensus.

MIR6075 by KLC1 expression — UCEC

Explore this box plot interactively →