KLC1

Across TCGA cell cohorts, KLC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,514 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLC1-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Negative regulation of calcium ion export across plasma membrane, and Microtubule nucleation. Each is linked with KLC1 in more than 17 cancer types. Because this analysis shows association rather than direction, both KLC1-to-partner and partner-to-KLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cilium assembly grouped by KLC1-low versus KLC1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLC1→partner) and Y-score (partner→KLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of cilium assembly →	+0.086	+1.058	<.001	.002	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.096	+1.115	<.001	<.001	3	17
OESOPHAGUS	Microtubule nucleation →	+0.119	+0.767	<.001	.001	3	16
URINARY_TRACT	tRNA transcription →	+0.100	+0.907	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Microtubule polymerization →	+0.116	+1.012	<.001	<.001	3	16
OESOPHAGUS	Regulation of ubiquitin-dependent protein catabolic process →	+0.091	+1.049	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,514 associations by consensus.

Negative regulation of cilium assembly by KLC1 expression — URINARY_TRACT

Explore this box plot interactively →