KLB

Across TCGA patient cohorts, KLB protein abundance is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLB-associated genes across cancer lineages are RGS4, CCN2, and TNFSF9. Each is linked with KLB in more than 1 cancer types. Because this analysis shows association rather than direction, both KLB-to-partner and partner-to-KLB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLB versus RGS4 in GBM, with a Pearson correlation of -0.86.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLB→partner) and Y-score (partner→KLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RGS4 →	-2.921	-0.690	.005	.005	3	1
GBM	CCN2 →	-1.502	-0.690	.007	.005	3	1
GBM	TNFSF9 →	-0.857	-0.690	.008	.005	3	1
GBM	ZFP36 →	-1.731	-0.690	.003	.005	3	1
GBM	ISLR →	-2.061	-0.690	.004	.005	3	1
GBM	BCL2A1 →	-1.512	-0.690	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

KLB vs RGS4 — GBM

Explore this scatter interactively →