KLB

Across TCGA pan-cancer cohorts, KLB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of KLB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KLB RNA is repressed in tumor relative to normal tissue. In most cancer types KLB is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and THCA are the cancer types where KLB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.982	<.001	11	view →
HNSC	All	IV	−0.519	<.001	11	view →
THCA	Male	All	−0.124	<.001	10	view →
LUAD	Male	II,III,IV	−1.915	<.001	9	view →
BRCA	All	III,IV	−2.882	<.001	8	view →
LUSC	Male	III,IV	−2.212	<.001	8	view →
LIHC	Male	All	+1.193	<.001	7	view →
KIRP	Male	All	−0.450	<.001	6	view →
CHOL	Female	All	−3.690	<.001	5	view →
READ	Female	All	−0.873	<.001	5	view →
KICH	All	II,III,IV	−0.499	<.001	4	view →
ESCA	All	All	−0.455	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

KLB–COAD

Open the COAD breakdown →