KLB

Across TCGA patient cohorts, KLB mutation is significantly associated with the RNA expression of many other genes, with 4,396 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLB-associated genes across cancer lineages are AIMP2, STOML2, and INO80B-WBP1. Each is linked with KLB in more than 3 cancer types. Because this analysis shows association rather than direction, both KLB-to-partner and partner-to-KLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AIMP2 grouped by KLB-low versus KLB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLB→partner) and Y-score (partner→KLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AIMP2 →	+0.678	+2.654	<.001	<.001	3	4
UCEC	STOML2 →	+0.416	+2.703	.001	<.001	3	4
SKCM	INO80B-WBP1 →	+0.076	+2.496	<.001	.002	3	3
LIHC	RPS6P23 →	+0.046	+4.647	<.001	.007	3	3
UCEC	COX5A →	+0.333	+2.209	.004	.001	3	3
UCEC	RNF227 →	+0.331	+2.766	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,396 associations by consensus.

AIMP2 by KLB expression — UCEC

Explore this box plot interactively →