KLB

Across TCGA cell cohorts, KLB RNA expression is significantly associated with the go_rna of many other GO terms, with 2,332 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLB-associated GO terms across cancer lineages are DNA replication proofreading, DNA-templated transcription termination, and Regulation of transcription by RNA polymerase I. Each is linked with KLB in more than 6 cancer types. Because this analysis shows association rather than direction, both KLB-to-partner and partner-to-KLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication proofreading grouped by KLB-low versus KLB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLB→partner) and Y-score (partner→KLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication proofreading →	+0.212	+0.125	.003	.009	3	7
BLOOD_Lymphoma	DNA-templated transcription termination →	+0.062	+0.047	<.001	<.001	3	7
BONE	Regulation of transcription by RNA polymerase I →	+0.124	+0.073	<.001	<.001	3	7
LIVER	Negative regulation of RNA catabolic process →	+0.053	+2.537	.001	.004	3	6
BLOOD_Lymphoma	Bleb assembly →	-0.557	-0.056	.003	.001	3	6
BLOOD_Lymphoma	Spermine biosynthetic process →	+0.107	+0.040	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,332 associations by consensus.

DNA replication proofreading by KLB expression — BONE

Explore this box plot interactively →