KLB

Across TCGA cell cohorts, KLB mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLB-associated genes across cancer lineages are CHIA, MS4A4A, and ALDH6A1. Each is linked with KLB in more than 1 cancer types. Because this analysis shows association rather than direction, both KLB-to-partner and partner-to-KLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHIA grouped by KLB-low versus KLB-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLB→partner) and Y-score (partner→KLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CHIA →	+1.476	+5.087	<.001	.004	3	1
LARGE_INTESTINE	MS4A4A →	+0.143	+2.678	<.001	.003	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.182	+3.064	<.001	.009	3	1
LARGE_INTESTINE	AMD1 →	+0.631	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PPA2 →	+0.785	+3.064	<.001	.009	3	1
LARGE_INTESTINE	TMEM107 →	+0.935	+3.067	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

CHIA by KLB expression — URINARY_TRACT

Explore this box plot interactively →