KIT

Across TCGA patient cohorts, KIT RNA expression is significantly associated with the protein abundance of many other proteins, with 15,143 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible KIT-associated proteins across cancer lineages are SYNPO2, SYNPO2_S820, and PPP1R12B. Each is linked with KIT in more than 6 cancer types. Because this analysis shows association rather than direction, both KIT-to-partner and partner-to-KIT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KIT versus SYNPO2 in CCRCC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KIT→partner) and Y-score (partner→KIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SYNPO2 →	+0.709	+0.733	<.001	<.001	3	7
OV	SYNPO2_S820 →	+1.030	+0.804	<.001	.003	3	7
UCEC	PPP1R12B →	+0.659	+0.871	.003	.003	3	7
CCRCC	KANK2 →	+0.527	+0.883	<.001	<.001	3	7
CCRCC	LMOD1 →	+0.827	+0.707	<.001	<.001	3	7
BRCA	SOD3 →	+0.996	+1.185	<.001	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,143 associations by consensus.

KIT vs SYNPO2 — CCRCC

Explore this scatter interactively →