KIT

Across TCGA cell cohorts, KIT mutation is significantly associated with the RNA expression of many other genes, with 1,039 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIT-associated genes across cancer lineages are DEFB108B, TAAR8, and H1-7. Each is linked with KIT in more than 1 cancer types. Because this analysis shows association rather than direction, both KIT-to-partner and partner-to-KIT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108B grouped by KIT-low versus KIT-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIT→partner) and Y-score (partner→KIT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB108B →	+0.097	+3.201	.005	.004	3	2
OVARY	TAAR8 →	+0.456	+5.339	<.001	<.001	3	2
OESOPHAGUS	H1-7 →	+0.084	+3.523	.001	.009	3	1
OESOPHAGUS	DYTN →	+0.086	+3.857	<.001	.002	3	1
SKIN	DYDC1 →	+0.122	+4.684	<.001	.002	3	1
SKIN	DEFB125 →	+0.031	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,039 associations by consensus.

DEFB108B by KIT expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →