KIRREL2

Across TCGA cell cohorts, KIRREL2 mutation is significantly associated with the RNA expression of many other genes, with 305 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIRREL2-associated genes across cancer lineages are TRPC7, OR8B4, and OR4E2. Each is linked with KIRREL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIRREL2-to-partner and partner-to-KIRREL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRPC7 grouped by KIRREL2-low versus KIRREL2-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIRREL2→partner) and Y-score (partner→KIRREL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TRPC7 →	+0.193	+4.217	.008	.005	3	1
OESOPHAGUS	OR8B4 →	+0.036	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4E2 →	+0.021	+3.544	<.001	.009	3	1
STOMACH	OR1E3 →	+0.250	+5.285	<.001	.003	3	1
LARGE_INTESTINE	PLA2G3 →	+1.176	+3.082	<.001	.007	3	1
LARGE_INTESTINE	CBY1 →	+0.553	+3.137	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 305 associations by consensus.

TRPC7 by KIRREL2 expression — URINARY_TRACT

Explore this box plot interactively →