KIR3DX1

Across TCGA patient cohorts, KIR3DX1 mutation is significantly associated with the RNA expression of many other genes, with 1,529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR3DX1-associated genes across cancer lineages are SKA1, MED8, and ITGAE. Each is linked with KIR3DX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIR3DX1-to-partner and partner-to-KIR3DX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by KIR3DX1-low versus KIR3DX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DX1→partner) and Y-score (partner→KIR3DX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.514	+2.081	.006	.001	3	3
SKCM	MED8 →	+0.299	+1.842	.002	<.001	3	3
UCEC	ITGAE →	+0.397	+1.781	<.001	.008	3	3
SKCM	DAP →	+0.404	+2.920	.005	.001	3	3
UCEC	IGHV3-20 →	+1.315	+2.459	<.001	<.001	3	3
ACC	RNU6-541P →	+0.539	+5.228	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,529 associations by consensus.

SKA1 by KIR3DX1 expression — UCEC

Explore this box plot interactively →