KIR3DL3

Across TCGA patient cohorts, KIR3DL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,215 significant associations in total. STAD shows the largest number of these associations.

The most reproducible KIR3DL3-associated GO terms across cancer lineages are Granzyme-mediated programmed cell death signaling pathway, Antigen receptor-mediated signaling pathway, and Defense response to tumor cell. Each is linked with KIR3DL3 in more than 15 cancer types. Because this analysis shows association rather than direction, both KIR3DL3-to-partner and partner-to-KIR3DL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Granzyme-mediated programmed cell death signaling pathway grouped by KIR3DL3-low versus KIR3DL3-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL3→partner) and Y-score (partner→KIR3DL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Granzyme-mediated programmed cell death signaling pathway →	+0.112	+0.170	<.001	<.001	3	16
TGCT	Antigen receptor-mediated signaling pathway →	+0.057	+0.147	<.001	<.001	3	15
ESCA	Defense response to tumor cell →	+0.073	+0.128	<.001	.006	3	15
TGCT	Interleukin-2-mediated signaling pathway →	+0.079	+0.147	<.001	<.001	3	15
TGCT	T cell receptor signaling pathway →	+0.053	+0.143	<.001	<.001	3	14
TGCT	Positive T cell selection →	+0.057	+0.145	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,215 associations by consensus.

Granzyme-mediated programmed cell death signaling pathway by KIR3DL3 expression — TGCT

Explore this box plot interactively →