KIR3DL3

Across TCGA pan-cancer cohorts, KIR3DL3 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of KIR3DL3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KIR3DL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KIR3DL3 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where KIR3DL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIR3DL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.016	.001	7	view →
LIHC	Male	All	−0.029	.029	1	view →
KICH	All	All	+0.020	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

KIR3DL3–KIRC

Open the KIRC breakdown →