KIR3DL3

Across TCGA patient cohorts, KIR3DL3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIR3DL3-associated genes across cancer lineages are PDCD4, TFRC, and RAD51. Each is linked with KIR3DL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both KIR3DL3-to-partner and partner-to-KIR3DL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by KIR3DL3-low versus KIR3DL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL3→partner) and Y-score (partner→KIR3DL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.524	-3.584	.005	.002	3	4
UCEC	TFRC →	+0.459	+1.906	.031	.016	3	3
LUAD	RAD51 →	+0.333	+3.016	<.001	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.205	-3.459	.002	.005	3	2
UCEC	MEK1 →	+0.437	+2.222	.002	.010	3	2
UCEC	MSH2 →	-0.343	-1.848	<.001	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PDCD4 by KIR3DL3 expression — UCEC

Explore this box plot interactively →