KIR3DL3

Across TCGA cell cohorts, KIR3DL3 RNA expression is significantly associated with the mutation status of many other genes, with 62 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIR3DL3-associated genes across cancer lineages are TRIML2, ZBTB41, and KIAA1671. Each is linked with KIR3DL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIR3DL3-to-partner and partner-to-KIR3DL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIML2 grouped by KIR3DL3-low versus KIR3DL3-high in LUNG_NSCLC_LUAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIR3DL3→partner) and Y-score (partner→KIR3DL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIML2 →	+5.228	+0.046	.005	<.001	3	2
LUNG_NSCLC_LUSC	ZBTB41 →	+3.584	+0.032	.003	<.001	3	1
LARGE_INTESTINE	KIAA1671 →	+3.700	+0.002	.009	<.001	3	1
LARGE_INTESTINE	ENTPD7 →	+6.022	+0.006	.001	<.001	3	1
LARGE_INTESTINE	NBPF15 →	+6.022	+0.006	.001	<.001	3	1
BLOOD_Leukemia	TRIM28 →	+2.635	+0.020	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

TRIML2 by KIR3DL3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →