KIFC3

Across TCGA patient cohorts, KIFC3 mutation is significantly associated with the RNA expression of many other genes, with 2,960 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIFC3-associated genes across cancer lineages are PRICKLE2, HMGB2, and SFXN1. Each is linked with KIFC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIFC3-to-partner and partner-to-KIFC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRICKLE2 grouped by KIFC3-low versus KIFC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIFC3→partner) and Y-score (partner→KIFC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRICKLE2 →	-0.480	-1.983	.001	.002	3	3
UCEC	HMGB2 →	+0.570	+3.021	.001	<.001	3	3
UCEC	SFXN1 →	+0.461	+1.947	<.001	<.001	3	3
UCEC	LEO1 →	+0.391	+2.695	.001	<.001	3	3
UCEC	PRDX2 →	+0.532	+1.979	<.001	<.001	3	3
UCEC	TYMSOS →	+0.834	+4.332	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,960 associations by consensus.

PRICKLE2 by KIFC3 expression — UCEC

Explore this box plot interactively →