KIF7

Across TCGA patient cohorts, KIF7 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF7-associated genes across cancer lineages are Caspase-7-cleavedD198, Annexin-1, and S6_pS240_S244. Each is linked with KIF7 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF7-to-partner and partner-to-KIF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KIF7-low versus KIF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF7→partner) and Y-score (partner→KIF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.673	+1.827	<.001	.002	3	3
UCEC	Annexin-1 →	+0.607	+3.321	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.252	+2.013	.033	.016	3	2
UCEC	BRCA2 →	-0.135	-2.764	<.001	.002	3	2
UCEC	Di-Ras3 →	-0.100	-1.295	.020	.010	3	2
UCEC	EGFR_pY1068 →	-0.177	-2.247	.015	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by KIF7 expression — UCEC

Explore this box plot interactively →