KIF5C

Across TCGA patient cohorts, KIF5C mutation is significantly associated with the RNA expression of many other genes, with 6,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF5C-associated genes across cancer lineages are MSANTD3, GPI, and NPAP1P7. Each is linked with KIF5C in more than 3 cancer types. Because this analysis shows association rather than direction, both KIF5C-to-partner and partner-to-KIF5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSANTD3 grouped by KIF5C-low versus KIF5C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5C→partner) and Y-score (partner→KIF5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSANTD3 →	+0.574	+2.148	<.001	<.001	3	4
UCEC	GPI →	+0.593	+2.534	<.001	<.001	3	4
LIHC	NPAP1P7 →	+0.035	+4.354	<.001	.006	3	3
UCEC	PRF1 →	+1.016	+2.158	<.001	<.001	3	3
UCEC	NDUFA6 →	+0.515	+2.148	<.001	<.001	3	3
UCEC	GAS2L1 →	+0.295	+1.785	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,193 associations by consensus.

MSANTD3 by KIF5C expression — UCEC

Explore this box plot interactively →