KIF5C

Across TCGA pan-cancer cohorts, KIF5C RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated KIF5C data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher KIF5C RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF5C expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

BRCA, KIRP, and UVM are the cancer types where KIF5C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	III,IV	0.879	0.666	<.001	81	view →
KIRP	DFS	Median	All	0.784	0.915	<.001	74	view →
UVM	DFS	Median	All	0.452	0.697	.006	43	view →
STAD	DFS	Quartile	II,III,IV	0.557	0.719	.005	40	view →
UCEC	DFS	Tertile	All	0.584	0.819	<.001	36	view →
PAAD	DFS	Median	All	0.384	0.199	.003	25	view →
KIRC	OS	Median	All	0.900	0.846	.005	16	view →
HNSC	DFS	Median	IV	0.405	0.252	.002	12	view →
ACC	DFS	Median	All	0.314	0.580	.012	11	view →
LGG	DFS	Median	All	0.468	0.297	.007	11	view →
COAD	DFS	Tertile	IV	0.234	0.819	.003	9	view →
OV	OS	Quartile	II,III,IV	0.662	0.748	.039	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

KIF5C–BRCA (DFS)

Open the BRCA breakdown →