KIF5C

Across TCGA patient cohorts, KIF5C mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIF5C-associated genes across cancer lineages are FoxM1, mTOR_pS2448, and ATM. Each is linked with KIF5C in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF5C-to-partner and partner-to-KIF5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by KIF5C-low versus KIF5C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5C→partner) and Y-score (partner→KIF5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.180	+1.387	.008	.001	3	3
UCEC	mTOR_pS2448 →	-0.115	-1.454	.003	.005	3	3
UCEC	ATM →	-0.672	-1.887	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.549	+1.797	<.001	.001	3	3
SKCM	GSK3-a-b →	+0.182	+2.840	.014	.033	3	2
SKCM	PCNA →	+0.333	+3.321	<.001	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

FoxM1 by KIF5C expression — UCEC

Explore this box plot interactively →