KIF5C

Across TCGA cell cohorts, KIF5C mutation is significantly associated with the RNA expression of many other genes, with 1,632 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIF5C-associated genes across cancer lineages are MRPS30, IDE, and PTCD3. Each is linked with KIF5C in more than 1 cancer types. Because this analysis shows association rather than direction, both KIF5C-to-partner and partner-to-KIF5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS30 grouped by KIF5C-low versus KIF5C-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF5C→partner) and Y-score (partner→KIF5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRPS30 →	+0.440	+3.169	.002	.006	3	2
LARGE_INTESTINE	IDE →	+0.762	+3.541	<.001	<.001	3	2
LARGE_INTESTINE	PTCD3 →	+0.577	+3.234	.001	.004	3	2
LARGE_INTESTINE	GFM2 →	+0.407	+2.743	.004	.001	3	2
LARGE_INTESTINE	HSPA4 →	+0.562	+2.743	<.001	.001	3	2
LARGE_INTESTINE	CD164L2 →	+0.688	+3.386	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,632 associations by consensus.

MRPS30 by KIF5C expression — LARGE_INTESTINE

Explore this box plot interactively →