KIF5B

Across TCGA pan-cancer cohorts, KIF5B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KIF5B data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KIF5B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KIF5B expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where KIF5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.489	.013	20	view →
LUAD	OS	Quartile	All	0.566	0.927	.002	20	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	12	view →
CCRCC	OS	Median	III,IV	0.898	0.576	.007	6	view →
LSCC	OS	Median	III,IV	0.766	0.932	.025	1	view →
HNSC	OS	Median	IV	0.853	0.630	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KIF5B–UCEC (DFS)

Open the UCEC breakdown →